Spurious Hemoglobin Barts Caused by Bilirubin
نویسندگان
چکیده
منابع مشابه
The Formation of Bilirubin from Hemoglobin
About 80 to 85 per cent of the fecal bile pigmients are believed to be derived from the hemoglobin of senescent erythrocytes that are destroyed in the reticuloendothelial system (1). It is not known, however, whether the hemoglobin of sequestered red cells is converted quantitatively to bilirubin and eventually to urobilinogen, or is in part metabolized to other products (2, 3). Earlier studies...
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Hemoglobin Barts hydrops fetalis (homozygous a-thalassemia) results from deletion of all 4 a-globin genes. It was previously considered a universally fatal condition; however,with recent advances in prenatal care and the availability of intrauterine blood transfusions, an increasing number of patients are now surviving into adulthood. Similar to patients with transfusion-dependent thalassemia d...
متن کاملQuantification of plasma hemoglobin in the presence of bilirubin with bilirubin oxidase.
Owing to the overlapping absorption bands of hemoglobin and bilirubin, spectrophotometric determination of plasma free hemoglobin has been plagued by the interference of bilirubin when the latter is present in significant concentrations. To resolve this problem, bilirubin oxidase from Myrothecium verrucaria has been used to remove bilirubin in icteric samples. The enzyme converts bilirubin to b...
متن کاملThe Relation of Chromatin to Hemoglobin and Bilirubin
1. Attention is directed to the diversity of opinion among investigators regarding the site and manner of hemoglobin formation in the body and its relation to bile pigment metabolism. 2. It is probable that in forming new hypotheses on this subject the earlier work of A. B. Macallum on the relation of chromatin to hemoglobin formation has not received sufficient consideration. 3. It has been sh...
متن کاملMechanism of interference by hemoglobin in the determination of total bilirubin. II. Method of Jendrassik-Grof.
Oxyhemoglobin in erythrocyte hemolysates interferes with the Jendrassik-Grof assay. Destruction of azobilirubin occurs when oxyhemoglobin is oxidized to methemoglobin during diazotization or to alkaline hematin with addition of alkaline tartrate. The most probable mechanism is by oxidation with an agent such as hydrogen peroxide or a related species resulting from hemoglobin oxidation. Methemog...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2006
ISSN: 0002-9173,1943-7722
DOI: 10.1309/73wjv2e0rtvqh0bb